(1)实现表面改性防护层与支架服役行为相匹配、与支架基体牢固结合、表面层均匀可控降解。避免支架变形时表面层开裂和服役过程中点蚀失效。(2)制备双药涂层实现有效抑制平滑肌细胞增生与快速完成内皮化功能,保证双药释放安全、有效,快速内皮化。(3)探明镁合金支架服役过程中的降解行为对所载药物稳定性及药物释放的影响。
(1) The surface modified protective layer is matched with the service behavior of the support, firmly combined with the support matrix, and the surface layer is uniform and controllable degradation. Avoid surface layer cracking when bracket deformation and pitting failure in service process. (2) Preparation of two-drug coating to effectively inhibit smooth muscle cell proliferation and rapidly complete the endothelialization function, ensuring safe, effective and rapid endothelialization of two-drug release. (3) The effects of degradation behavior on the stability and drug release of magnesium alloy scaffolds during service were investigated.