本发明涉及介入医疗器械领域,尤其涉及一种改善镁合金血管支架耐蚀性能的表面改性方法,适用于血管腔内狭窄治疗、携载抑制平滑肌增殖和促进内皮化的新型双药可降解镁合金血管支架。该方法通过在镁合金支架上制备具有促进内皮化功能的药物涂层,加速支架植入后的内皮化过程,改善支架的服役环境,从而提高镁合金血管支架的耐腐蚀性能。该镁合金血管支架除载有抑制内膜过度增殖类药物外,还携带促进内皮化的药物。在支架植入病变血管后,通过促内皮化药物的作用,实现损伤部位的快速内皮修复,从而改善镁合金支架的服役环境,从另一角度提高可降解镁合金血管支架的耐腐蚀性能。
The invention relates to the field of interventional medical devices, in particular to a surface modification method for improving the corrosion resistance of magnesium alloy vascular scaffolds, which is suitable for the treatment of endovascular stenosis, carrying a new dual-drug degradable magnesium alloy vascular scaffolds that inhibit smooth muscle proliferation and promote endothelialization. In this method, drug coating with the function of promoting endothelialization was prepared on magnesium alloy scaffolds to accelerate the endothelialization process after stent implantation and improve the service environment of the scaffolds, thus improving the corrosion resistance of magnesium alloy vascular scaffolds. The magnesium alloy stent not only contained drugs to inhibit intima hyperproliferation, but also drugs to promote endothelialization. After implantation of the stent into the lesion vessels, rapid endothelial repair of the injured site was realized through the action of endothelialization drugs, so as to improve the service environment of the magnesium alloy stent and improve the corrosion resistance of the degradable magnesium alloy vascular stent from another perspective.