本发明公开了一种具有含铜涂层的可降解镁合金心血管支架。将不同浓度的载铜微球通过一定的方式梯度化地固定/分散在镁合金支架表面的聚合物载体中,从而可实现镁合金支架的生物功能化。其中,功能化载铜微球的固定方式包括化学接枝、物理共混、静电作用等。这种具有生物功能化含铜涂层的镁合金支架植入体内后可以加速血管内皮化,抑制动脉平滑肌过度增生,减少血小板黏附,从而避免因镁合金支架网丝比传统惰性金属支架粗大,而发生内皮化缓慢、炎性反应及血栓等不良事件。
The invention discloses a degradable magnesium alloy cardiovascular stent with a copper-containing coating. The biofunctionalization of magnesium alloy scaffolds can be realized by fixing/dispersing different concentrations of cu-loaded microspheres into polymer carriers on the surface of magnesium alloy scaffolds in a gradient manner. Among them, the fixation methods of functionalized copper microspheres include chemical grafting, physical blending, electrostatic action, etc. This biofunctional copper coated magnesium alloy stent can accelerate vascular endothelialization, inhibit excessive proliferation of arterial smooth muscle and reduce platelet adhesion after implantation, thus avoiding adverse events such as slow endothelialization, inflammatory reaction and thrombosis due to the larger mesh of magnesium alloy stent than traditional inert metal stent.