By adding a ppropriate amount of oxidant and solvent,a novel quaternary ammonium salt was“one-pot ”synthesized using quinoline and benzyl chloride, which was studied asacidizing corrosion inhibitor. The results show that the novel quaternary ammonium salt exhibits much bette rinhibition performance than the common quinoline quaternary ammonium salt(BQC) in15% HCl solution at90 ℃. The corrosion rate of N80 steel sheet was 4.21g·/m2/h when 0.1% low dosage was used alone, which can meet the industry standard requirements. The novel type quaternary ammonium salt inhibitor formed ana dsorption layer on the surfac eof N80 steel sheet, Its inhibition mechanism was a mixed type inhibitor which mainly inhibits the anodic reaction.