Oxidative coupling has been widely used in the construction of C−C, C−N and C−S bond. Nevertheless, the method of oxidative coupling is rarely used to construct C−P bond and has not attracted enough attention. Herein, we found an innovative and simple method to construct C−P bond by oxidative coupling. Through the method, we successfully constructed the C−P bond on quinoxaline, and using this method, a series of quinoxaline derivatives were synthesized in good to excellent yield. Furthermore, the method is also suitable for large-scale production and may be used to industrial application