In nickel-doped tungsten alloys, 1-4wt% of nickel is usually used to accelerate the densification in the traditional sintering process, but the cost is the limitation of the use temperature due to the formation of a liquid phase. In order to break the predicament, in this work, 0.1wt% of Ni was alloyed into the W matrix to achieve a relative density of 98%. The densification and grain growth behavior of pure and nickel-doped tungsten compacts were studied, and a potential solid solution alloying accelerated sintering mechanism was explored. First-principles calculations show that after Ni doping, the transition barrier of vacancies in the W system is reduced by 34%. Therefore, this alloying process is conducive to the lattice diffusion of tungsten, thereby improving the sintering performance and usability of the tungsten-nickel alloy.