一种血管支架材料表面修饰方法、及其修饰后得到的血管支架材料和应用，属于心血管支架材料表面修饰技术领域，本发明的反应过程与机理主要分为两个部分。第一部分为材料表面多巴胺（简称PDA）聚合薄膜的沉积。首先多巴胺在有氧、碱性条件下可以引发温和的自聚‑交联反应，可与材料发生螯合和自聚合反应，形成稳定的多巴胺聚合物薄膜。第二部分为PDA薄膜表面外泌体的修饰。将沉积有PDA薄膜的材料浸没在外泌体悬液中，反应一段时间即可得到聚多巴胺/外泌体修饰层。由于外泌体带正电属性，可与带负电荷的PDA薄膜发生静电作用，因此所构建的聚多巴胺/外泌体修饰层可与材料稳定结合。

A method for modifying the surface of a vascular stent material, and the vascular stent material obtained after modification and application thereof belong to the technical field of surface modification of a cardiovascular stent material. The reaction process and mechanism of the present invention are mainly divided into two parts. The first part is the deposition of a polymeric film of dopamine (PDA for short) on the surface of the material. First of all, dopamine can initiate a mild self-polymerization-crosslinking reaction under aerobic and alkaline conditions, and can chelate and self-polymerize with the material to form a stable dopamine polymer film. The second part is the modification of exosomes on the surface of PDA film. The material deposited with the PDA film is immersed in the exosomal suspension and reacted for a period of time to obtain the polydopamine/exosomes modified layer. Due to the positively charged properties of exosomes, they can interact electrostatically with negatively charged PDA films, so the constructed polydopamine/exosomes modified layer can be stably combined with the material.