在PLCL血管内壁中仅少量ECs不均匀地分布。然而,大量的ECs均匀分布在PGD-CAG/ACH11内部纤维结构中。更为重要的是,PLCL血管腔内表面没有CD31阳性细胞的存在,而PGD-CAG/ACH11则表现了明显的内皮细胞再生,分布更广泛,即使内皮层不是非常完整。研究证明,在将CAG和ACH11固定在材料表面后,其内皮化程度显著提高。这主要归因于CAG多肽的ECs选择性粘附。综上,与PLCL相比,PGD-CAG/ACH11血管具有更好的血液相容性和表面内皮化,这也与之前的体外生物相容性测试结果相一致。
Only few numbers of ECs were unevenly distributed in the graft wall of PLCL graft. Conversely, amounts of ECs were homogeneously distributed within the internal structure of PGD-CAG/ACH11 graft. Importantly, PLCL graft did not show the presence of CD31-positive cells on the luminal side, whereas PGD-CAG/ACH11 graft showed endothelial regeneration in the lumen even though endothelial coverage was not complete. Thus, the endothelialization rate of vascular graft was significantly improved after the immobilization of CAG and ACH11 onto surface. This was mainly attributed to the ECs-selective attachment of CAG peptide immobilized on the grafts. This in vivo result indicated that the PGD-CAG/ACH11 graft possessed better hemocompatibility and surface endothelialization compared with that of PLCL, which was consistent with the in vitro biocompatibility tests.