与未修饰的对照组(PLCL和PG)相比,修饰后样品的细胞迁移距离和迁移数量显著增加,而迁移密度几乎没有差异。而且,在PGD和所有多肽官能化的表面之间的HUVECs的迁移行为没有明显差异,这表明CAG和ACH11多肽可能对EC迁移没有太大影响。上述结果表明,多巴胺涂层可有效促进ECs的迁移,而CAG/ACH11 多肽的进一步接枝则没有明显作用。此外,CAG修饰表面上的细胞形态和细胞排列得到有效改善,这可能归因于CAG良好的生物活性,为细胞生长提供更好的生物学微环境。
Compared with non-modified controls (PLCL and PG), the migration distance and amount of migrated HUVECs were remarkably increased on the modified samples, while the density of migrated HUVECs exhibited a negligible difference among all surfaces. Moreover, there were no significant difference was found in the HUVECs migration between PGD and all peptide-functionalized surfaces, which indicated that the CAG and ACH11 peptide might has no considerable effect on ECs migration. These above results indicated that dopamine coating significantly increased EC migration, and further the grafting of CAG/ACH11 peptide has no considerable effect. Moreover, the cell morphology and cytoskeletal arrangement on the CAG-modified surfaces have been improved, which might be attributed to the CAG bioactivity of supporting better microenvironment for cell growth.