v> Biomedical patches play fundamental roles in various applications such as wound closure and tissue

regeneration. The hybrid patches integrating versatile properties will prominently improve the

therapeutic effects in clinical applications. Herein, an epoxy network loading curcumin and Ti3C2Tx

MXenes were developed as a hybrid biomedical patch. The hybrid patch was basically prepared

through an epoxy/thiol curing chemistry, and its topological structure can be destructed and

rearranged as a vitrimer does due to the active transesterification at high temperature. The resulted

hybrid patch exhibits shape-morphing capability, multi-substrate adhesion, self-healing ability, and

photothermal effects under 980 nm near infrared (NIR). Additionally, the as-prepared hybrid patch

possesses strong UV-shielding, excellent oxidation resistance (ROS scavenging efficiency was 89.3%

in 3 min), highly effective antibacterial vitality (more than 99%) against S.aureus and E.coli, and

good cytocompatibility. As a proof of concept, the present multifunctional hybrid patch broadens

the potential applications in biomedical field.