本发明公开了一种用于镁基医用材料及器件的仿生多功能涂层及制备、用途。所述涂层的制备包括以下步骤:1)碱性催化剂‑有机溶剂的制备:将碱性催化剂溶于有机溶剂中混合;2)多巴胺单体溶液制备:将多巴胺单体溶于碱性催化剂‑有机溶剂中混合;3)涂层制备:将镁基材料或器件浸入多巴胺单体溶液中,通过自聚合反应原位生长获得聚多巴胺膜层,即可。本发明方法解决了在水溶液环境制备聚多巴胺膜由于镁基易腐蚀导致膜层缺损的问题;制备的涂层具有以下特点及功能:膜层致密完备,显著提高镁基耐腐蚀性能,延缓降解;显著提高镁基材料及器件的生物相容性;还可作为中间层实现二次功能化及多功能化;操作工艺简便,涂层与基体结合力强,厚度可控。
The invention discloses a bionic multifunctional coating for magnesium based medical materials and devices, and its preparation and application. The preparation of the coating includes the following steps: 1) alkaline catalyst organic solvent preparation: the alkaline catalyst dissolved in organic solvent mixed; 2) Preparation of dopamine monomer solution: the dopamine monomer is dissolved in alkaline catalyst organic solvent mixed; 3) Preparation of coating: Immersion of magnesium-based materials or devices in dopamine monomer solution, in-situ growth of polydopamine film through self-polymerization reaction, can be. The invention solves the problem of film defect caused by magnesium base corrosion in preparing polydopamine film in aqueous solution environment; The prepared coating has the following characteristics and functions: dense and complete film layer, significantly improve the corrosion resistance of magnesium base, delay degradation; Significantly improve the biocompatibility of magnesium substrate materials and devices; It can also be used as an intermediate layer to realize secondary and multi-functionalization. The operation process is simple, the coating and substrate bonding force is strong, the thickness is controllable.