一种医用植入体表面兼具优良生物相容性和抗菌性复合涂层的制备方法，涉及医用植入体。将待处理的医用植入体预处理；将预处理后的医用植入体置于混合酸溶液中刻蚀；配制含ε‑聚赖氨酸的钙磷沉积液，在医用植入体表面构筑磷酸八钙与ε‑聚赖氨酸复合涂层，得医用植入体表面兼具优良生物相容性和抗菌性复合涂层。将ε‑聚赖氨酸引入磷酸八钙膜层的构筑过程中，可优化磷酸八钙膜层表面形貌，以利于细胞的生长和黏附，从而在保持磷酸八钙膜层优良的生物活性和生物相容性的基础上，显著提高植入体的抗菌性。对于不同的医用植入体，均可直接在其表面构筑磷酸八钙与ε‑聚赖氨酸复合涂层，从而有效增强植入体表面的生物学性能和抗菌性。

The invention discloses a preparation method of a composite coating with excellent biocompatibility and antibacterial property on the surface of a medical implant, and relates to the medical implant.The method comprises the following steps of pretreating a to-be-treated medical implant; putting the pretreated medical implant into a mixed acid solution to be etched; and preparing an calcium-phosphorus deposition solution containing epsilon-polylysine, and constructing octacalcium phosphate and epsilon-polylysine composite coating on the surface of the medical implant so as to obtain the composite coating with the excellent biocompatibility and antibacterial property on the surface of the medical implant. According to the method, in the construction process of introducing the epsilon-polylysine into an octacalcium phosphate film layer, the surface morphology of the octacalcium phosphate film layer can be optimized, so that growth and adhesion of cells can be facilitated, and the antibacterial property of the implant is remarkably improved on the basis that the excellent biological activity and biocompatibility of the octacalcium phosphate film layer are kept; and for different medical implants, the octacalcium phosphate and epsilon-polylysine composite coating can be directly constructed on the surfaces of different medical implants, so that the biological performance and the antibacterial property of the implant surface are effectively enhanced.