一种在钛或钛合金表面制备生物活性复合涂层的方法，涉及人体硬组织替换材料表面处理。提供可显著优化植入体材料表面钙磷盐复合膜层的晶体形貌，提高生物相容性和生物活性，可用于钛及其合金植入物表面生物活性优化改性的一种在钛或钛合金表面制备生物活性复合涂层的方法。1)将钛或钛合金表面预处理；2)配制含氟电解液，以预处理后的钛或钛合金为阳极，铂片为阴极，浸没在含氟电解液中进行阳极氧化，制备TiO2纳米管膜层；3)配制含钙磷物种和短肽的电解液，以阳极氧化后的钛或钛合金为工作电极，铂片为对电极进行恒电流电沉积，即完成在钛或钛合金表面制备生物活性复合涂层，该生物活性复合涂层为钙磷盐/短肽复合膜层。

 The invention relates to human hard tissue substitution material surface treatment and discloses a method for preparing a biological active composite coating on the surface of titanium or titanium alloy. The method for preparing the biological active composite coating on the surface of the titanium or the titanium alloy can obviously optimize the crystal morphology of a calcium and phosphate salt composite film on the surface of implant material, can improve the biocompatibility and the biological activity and can be used for optimizing and modifying the biological activity on the surfaces of titanium and titanium alloy implants. The method comprises the steps of 1, pre-treating the surface of the titanium or the titanium alloy; 2, preparing fluorine-containing electrolytic solutions, immersing the pretreated titanium or the pretreated titanium alloy serving as the anode and a platinum sheet serving as the cathode into the fluorine-containing electrolytes for carrying out anodic oxidation, and preparing a titanium dioxide nanotube film; 3, preparing electrolytic solutions containing calcium and phosphate species and oligopeptide, carrying out continuous-current electro-deposition with the titanium or the titanium alloy subjected to anodic oxidation as the working electrode and the platinum sheet as the counter electrode, and finally completing the process of preparing the biological active composite coating on the surface of the titanium or the titanium alloy, wherein the biological active composite coating is a calcium and phosphate salt/oligopeptide composite film.