一种在医用植入材料表面制备无毒法抗菌涂层的方法，涉及医用植入材料。提供可显著降低植入体材料表面银复合膜层的细胞毒性，并保持优异抗菌性，主要应用于骨、齿替换及组织再生医学的植入物表面抗菌改性的一种在医用植入材料表面制备无毒法抗菌涂层的方法。将待处理的医用植入材料预处理；配制含AgNO3、短肽和电解质或还原性物质的溶液，在医用植入材料表面构筑纳米银/短肽复合膜层。可显著降低植入体材料表面纳米银膜层的细胞毒性，且保持优异的抗菌特性。可应用于多种植入物表面的无毒抗菌改性。工艺简单、投资少、可广泛应用于医用植入体表面改性，可规模化生产。

The invention discloses a method for preparing a nontoxic antibacterial coating on the surface of a medical implant material and relates to a medical implant material. The invention provides the method for preparing the nontoxic antibacterial coating on the surface of the medical implant material, wherein the cytotoxicity of a silver composite membrane layer on the surface of an implant material can be remarkably reduced while excellent antibacterial property is maintained, and the method is mainly applied to the antibacterial modification of the implant surface in bone and tooth replacement and tissue regenerative medicine. The method comprises the following steps: pretreating the to-be-treated medical implant material; preparing a solution containing AgNO3, short peptide and electrolyte or reductive substance; and building a nano silver/short peptide composite membrane layer on the surface of the medical implant material. The cytotoxicity of the nano silver membrane layer on the surface of the implant material can be remarkably reduced while excellent antibacterial property is maintained. The method can be applied to the nontoxic antibacterial modification of the surfaces of multiple implants. The method is simple in technology, requires small investment and can be widely applied to the surface modification of medical implants while large-scale production can be realized.