本发明公开了一种具有消除表面生物膜功能的医用钛植入体的制备方法，包括以下步骤：首先通过“一锅法”合成介孔聚多巴胺(MPDA)纳米颗粒，同时通过双酸腐蚀以及氨基化硅烷偶联剂(APTES)修饰构建表面氨基化的钛材，通过Michael加成反应将MPDA纳米颗粒整合到钛材表面；其次，锚定在钛材表面的MPDA可作为光热材料和光敏剂载体，MPDA中具有丰富的芳香环可通过π‑π堆积相互作用促进了光敏剂(吲哚菁绿，ICG)的大量负载；最后，在MPDA表面可通过Michael加成反应进一步修饰生物相容性的RGD多肽，将所改性后的钛材命名为Ti‑M/I/RGD。

The invention discloses a method for preparing a medical titanium implant with a function of eliminating a surface bio-membrane. The method comprises the following steps: firstly, synthesizing mesoporous dopamine (MPDA) nanoparticles by a one-pot method, constructing a surface aminated titanium material through double-acid corrosion and aminopropyltriethoxysilane (APTES) modification, and integrating the MPDA nanoparticles to the surface of the titanium material through a Michael addition reaction; secondly, promoting massive load of a photosensitizer (indocyanine green, ICG) through pi-pi stacking interaction with rich aromatic ring in the MPDA which is anchored to the surface of the titanium material and can be used as a photothermal material and a photosensitizer vector; and finally further modifying biocompatible RGD polypeptide on the MPDA surface through the Michael addition reaction and naming the modified titanium material Ti-M/I/RGD.