The invention provides a hot rolling lubrication process method for a titanium alloy seamless tube. The method comprises the steps that glass powder lubricants are prepared; mica-based lubricants are prepared; a heated titanium alloy seamless tube blank is subjected to cross piercing, a high-temperature hollow tubular billet is obtained, and the temperature of the inner surface of the tubular billet is 950-1100 DEG C; the glass powder lubricants are blown into the inner surface of the tubular billet, so that the inner surface of the tubular billet is covered with the glass powder lubricants, and the glass powder lubricants is in a molten state under the condition of the high temperature higher than 900 DEG C; and a core rod is preheated to 80-120 DEG C and conveyed to a core rod lubrication station, and mica-based lubricant solutions are sprayed onto the surface of the core rod through a nozzle, so that the sprayed mica-based lubricants adhere to the surface of the core rod, and then, the core rod is inserted into the tubular billet and fed into a tube rolling rack to be subjected to hot rolling. The hot rolling lubrication process method has the effects that a hot rolling tool is lubricated through the method, so that the hot rolling load in the titanium alloy tube producing process is reduced by 8%-12%, annular elephant skins on the surface of the core rod are disappeared, the service life of the core rod is prolonged by 15%, and micro cracks and scratches of the inner surface of the titanium alloy tube are significantly decreased.
