一种高性能生物可降解Zn-Cu-Li-X合金及制备和应用方法，属于生物可降解医用材料领域。本发明所述Zn-Cu-Li-X合金中X为Mg，Ca，Sr，Mn，Fe，Ag，Co，Cr，Ti，Sn，Si，Se以及Ge中一种，Zn为余量。经真空熔炼、高温均匀化处理、预热、塑性变形后获得细密的纳米析出相，或单质元素，或Zn+β-LiZn₄连续片层组织和富Cu相，使得合金兼具高强度和高塑性。所述合金的室温拉伸屈服强 度为250～650MPa ，抗拉强 度为300～800MPa，延伸率为20～80％；在模拟体液中均匀降解，降解速率为0.011～0.5mm/y；对L929成骨纤维细胞和MG63细胞的毒性低于2级，满足多种人体植入器件材料的使用要求，具有推广价值和广泛的应用前景。

The invention relates to a high performance biodegradable Zn-Cu-Li-X alloy and a preparation and application method thereof, belonging to the field of biodegradable medical materials. In the Zn-Cu-Li-X alloy mentioned in the invention, X is one of Mg, Ca, Sr, Mn, Fe, Ag, Co, Cr, Ti, Sn, Si, Se and Ge, and Zn is the remainder. After vacuum melting, homogenization treatment at high temperature, preheating and plastic deformation, fine nano-precipitates, or elemental elements, or Zn+ β-LiZn₄ continuous lamellar structure and Cu-rich phase were obtained, which made the alloy have high strength and high plasticity. The tensile yield strength of the alloy at room temperature is 250 ~ 650MPa, the tensile strength is 300 ~ 800MPa, and the elongation is 20 ~ 80%. The degradation rate was 0.011 ~ 0.5mm/y in the simulated body fluids. The toxicity to L929 osteofibroblasts and MG63 cells was lower than grade 2, which met the requirements of many kinds of human implant materials, and had a wide application prospect and promotion value.