本发明涉及生物材料技术领域，提供了一种用于软骨缺损修复的镁基可注射复合水凝胶及其制备。本发明首先在镁粉颗粒表面制备厚度为20纳米‑5微米的涂层保护层，提高镁粉颗粒的耐腐蚀性能，然后将涂层镁粉颗粒均匀掺入到的复合水凝胶中，在外界或内源环境下可自发响应形成稳定的三维互穿网络微结构，具有适宜的力学性能和降解性能、并可实现镁离子和氢气的可持续控释。该镁基复合水凝胶仅需通过微创注射即可应用于软骨损伤修复，尤其是骨关节炎下的组织再生。具有治疗和减缓炎症，促进干细胞、软骨细胞增殖和成软骨分化活性，可降低病患痛苦、提高疗效。

The present invention pertains to the field of biomaterials technology, providing a magnesium-based injectable composite hydrogel for the repair of cartilage defects and its preparation method. The invention initially creates a coating protective layer with a thickness of 20 nanometers to 5 micrometers on the surface of magnesium powder particles, enhancing their corrosion resistance. The coated magnesium powder particles are then uniformly mixed into a composite hydrogel, which can spontaneously respond to form a stable three-dimensional interpenetrating network microstructure under external or endogenous conditions, possessing suitable mechanical properties and degradation performance, and enabling sustainable controlled release of magnesium ions and hydrogen gas. This magnesium-based composite hydrogel can be applied to cartilage damage repair and tissue regeneration under osteoarthritis through minimally invasive injection. It has the ability to treat and alleviate inflammation, promote the proliferation and chondrogenic differentiation activity of stem cells and chondrocytes, thereby reducing patient suffering and improving therapeutic outcomes.