本发明涉及一种促进蛇床子素透皮吸收的凝胶纳米纤维制备方法及其应用，属于生物材料领域。所述促进蛇床子素透皮吸收的凝胶纳米纤维制备方法如下：A、将氨基酸衍生物加热‑冷却，制得含纳米纤维的水凝胶；B、将步骤A得到的含纳米纤维水凝胶加入含有蛇床子素的药膏中，并进行物理搅拌至混合均匀，使得蛇床子素吸附在凝胶纳米纤维上，即得载有蛇床子素的凝胶纳米纤维载体。所述的凝胶纳米纤维载体可有效促进蛇床子素透皮吸收。

The invention relates to a preparation method and application of a gel nanofiber for promoting transdermal absorption of osthole, which belongs to the field of biological materials. The method for preparing the gel nanofiber for promoting transdermal absorption of osthole includes the following steps: A, heating and cooling an amino acid derivative to prepare a nanofiber-containing hydrogel; B, adding the nanofiber-containing hydrogel obtained from step A into an ointment containing osthole, and physically stirring until uniformly mixed, so that the osthole is adsorbed onto the gel nanofibers, thereby obtaining the gel nanofiber carrier loaded with osthole. This gel nanofiber carrier can effectively promote the transdermal absorption of osthole.