本发明涉及一种可以监测创面微环境的手性水凝胶创面敷料及制备方法和应用，属于生物材料领域。所述水凝胶创面敷料的制备方法如下：A、通过化学合成制备基于以芳香环为中心核、L-氨基酸为对称侧链的手性超分子组装基元；B、将步骤A得到的分子溶解于海藻酸盐溶液中，所得溶液转移至模具中，静置冷却进行首次超分子螺旋纤维与高分子长链交联，在模具中形成预凝胶；C、将成型后的预凝胶浸泡在盐溶液中进行第二次高分子长链交联，交联产物洗涤后，即得。所述的可以监测创面微环境的水凝胶创面敷料具有良好的生物相容性，可有效促进创面愈合，同时可以实时监控创口附近微环境的pH值，指示伤口的愈合情况。

This invention relates to a chiral hydrogel wound dressing that can monitor the wound microenvironment, its preparation method, and application, which belongs to the field of biomaterials. The preparation method of the hydrogel wound dressing is as follows: A, prepare chiral supramolecular assembly units with an aromatic ring as the central core and L-amino acids as symmetric side chains through chemical synthesis; B, dissolve the molecules obtained from step A in an alginate solution, transfer the solution to a mold, and allow it to stand and cool to undergo the first intermolecular helical fiber crosslinking with long polymer chains, forming a pre-gel in the mold; C, immerse the shaped pre-gel in a salt solution for the second crosslinking of long polymer chains, and after washing the crosslinked product, the dressing is obtained. The chiral hydrogel wound dressing that can monitor the wound microenvironment has good biocompatibility, can effectively promote wound healing, and simultaneously can monitor the pH value of the microenvironment near the wound in real-time, indicating the healing condition of the wound.