本发明提供一种可控降解镁基仿生双相支架及其制备方法和应用。所述支架包括多孔镁支架、水凝胶、陶瓷涂层；所述多孔镁支架包括由上到下设置的软骨相支架、软骨下骨相支架；所述软骨相支架的孔隙及外表面设置水凝胶，软骨下骨相支架的表面设置陶瓷涂层。本发明从仿生的角度出发，模仿关节组织（上层软骨，下层软骨下骨）的结构和力学等特点设计梯度孔隙率的三维联通的多孔镁支架；同时根据关节组织成分和生物学性能等特点，在支架内部填充水凝胶（上层软骨相）和在其表面制备生物活性陶瓷涂层（下层软骨下骨相），调控双相镁支架的降解速率，降低细胞毒性；同时提高其生物相容性和生物活性，实现内源性软骨-软骨下骨一体化修复。

The present invention provides a controllable degradation magnesium based biomimetic biphasic scaffold and its preparation method and application. The support comprises a porous magnesium support, a hydrogel and a ceramic coating; The porous magnesium scaffold comprises a cartilage phase scaffold and a subchondral bone phase scaffold arranged from top to bottom; The pores and the outer surface of the cartilage phase scaffold are provided with hydrogels, and the surface of the subchondral bone phase scaffold is provided with a ceramic coating. The present invention designs a three-dimensional interconnected porous magnesium scaffold with gradient porosity by mimicking the structural and mechanical characteristics of joint tissues (upper cartilage, lower subchondral bone) from a biomimetic perspective; At the same time, according to the characteristics of joint tissue composition and biological performance, hydrogel (upper cartilage phase) was filled in the scaffold and bioactive ceramic coating (lower cartilage bone phase) was prepared on its surface to regulate the degradation rate of biphasic magnesium scaffold and reduce cytotoxicity; Simultaneously improving its biocompatibility and biological activity, achieving integrated repair of endogenous cartilage subchondral bone.