本发明公开了一种简单绿色通用的合成多 种四吡啶基环丁烷的方法，所述方法涉及1 ,2 ,3 , 4‑(4‑吡啶基)环丁烷，1 ,2 ,3 ,4‑(3‑吡啶基)环丁 烷，1 ,2 ,3 ,4‑(2‑吡啶基)环丁烷的合成。本申请 所述合成方法以二吡啶基乙烯(如1 ,2‑二(4‑吡 啶基)乙烯，1 ,2‑二(3‑吡啶基)乙烯，1 ,2‑二(2‑ 吡啶基)乙烯)为原料，通过光照射1 ,2‑二(4‑吡 啶基)乙烯，1 ,2‑二(3‑吡啶基)乙烯，或1 ,2‑二 (2‑吡啶基)乙烯溶液结冰后的冷冻溶液，分离纯 化后得到相应的四吡啶基环丁烷(如1 ,2 ,3 ,4‑ (4‑吡啶基)环丁烷，1 ,2 ,3 ,4‑(3‑吡啶基)环丁 烷，或1 ,2 ,3 ,4‑(2‑吡啶基)环丁烷)。该方法不需 要使用有机或金属共晶分子，不需要后期分离， 不需要使用乙醇之外的其它有机物，操作简单， 绿色无污染。

The present invention discloses a simple green and versatile method for synthesizing a variety of tetrapyridylcyclobutanes, said method relates to the synthesis of 1 ,2 ,3 ,4-(4-pyridyl)cyclobutane, 1 ,2 ,3 ,4-(3-pyridyl)cyclobutane, 1 ,2 ,3 ,4 -(2-pyridyl)cyclobutane synthesis. The synthesis method described in the present application is based on the synthesis of dipyridyl vinyls (e.g., 1 ,2-bis(4-pyridyl)vinyl, 1 ,2-bis(3-pyridyl)vinyl, 1 ,2-bis(2- pyridinyl)ethylene) as raw material by light irradiation of 1 ,2-bis(4-pyridinyl)ethylene, 1 ,2-bis(3-pyridinyl)ethylene, or 1 ,2-bis(2-pyridinyl ) ethylene solutions frozen after icing, and isolated and purified to obtain the corresponding tetrapyridylcyclobutane (e.g., 1 ,2 ,3 ,4-(4-pyridyl)cyclobutane, 1 ,2 ,3 ,4-(3-pyridyl)cyclobutane, or 1 ,2 ,3 ,4 -(2-pyridyl)cyclobutane). The method does not require the use of organic or metal eutectic molecules, does not require post-separation, does not require the use of organic substances other than ethanol, and is simple, green and non-polluting.