本发明公开了一种复合骨水泥、制备方法及其应用和一种骨修复材料，所述复合骨水泥，按质量百分比由包括50％～80％固相粉剂和20％～50％固化液的原料混合制得，所述固相粉剂包括磷酸盐和/或磷酸酸式盐，所述固化液包括壳聚糖、透明质酸、有机酸和水。本发明的复合骨水泥具有良好的可注射性、生物活性、骨传导和修复能力，固化得到的骨修复材料具有良好的力学性能，其表面易于细胞的粘附，同时能够不影响细胞的分化能力，本发明复合骨水泥能够用于骨缺损的填充和修复，以及作为药物载体治疗骨科相关疾病。

The invention discloses compound bone cement, a preparation method and application of the compound bone cement, and a bone repair material. The compound bone cement is prepared by mixing the following raw materials in percentage by mass: 50-80% of solid phase powder and 20-50% of setting liquid, wherein the solid phase powder comprises phosphate and/or acidic salt of phosphoric acid; the setting liquid comprises chitosan, hyaluronic acid, organic acids and water. The compound bone cement has excellent syringeability, biological activity and bone conduction and repair ability, the set bond repair material has an excellent mechanical property, the surface of the material is easy for cell adhesion, and the cell differentiation ability cannot be influenced. The compound bone cement disclosed by the invention can be used for bone defect filling and repairing and serves as a drug carrier to be used for treating orthopedic related diseases.