This task belongs to the first topic of the general project "R&D of fully degraded mo alloy coronary drug-eluting stent". In view of the problems such as vasomotor dysfunction and inflammatory reaction of foreign bodies caused by permanent retention of traditional non-degradable metal stents in vessels, as well as the current situation that commercial magnesium alloys cannot meet the requirements of clinical use, the research and development of fully degradable magnesium alloys for vascular stents with "biosafety, mechanical matching and controllable degradation" was conducted. This project aims to solve the material design problem of "biocompatibility, strength and toughness, and uniform degradation" of magnesium alloy stents, and the preparation problems related to melt deep purification and solidification control of biodegradable magnesium alloy. Around the key scientific and technical issues, this task will further optimize magnesium alloy components: to carry out the depth melt purification,grain refinement and homogenization of solidification microstructure, deformation processing key preparation technology research and development. Study the effects of alloy elements and purity on the mechanical properties, degradation behavior and biocompatibility. To further improve the comprehensive properties of magnesium alloys, develop magnesium alloy materials for stents with excellent biocompatibility, high strength and toughness, and a controllable degradation, and establish enterprise standards for biodegradable magnesium alloy. The project is led by the National Engineering Research Center of Light Alloy Net Forming, Shanghai Jiao Tong University. Research results will provide reliable material basis for the entire project. It is the key to realize its final clinical application. Project research products are expected to become a new generation stents as alternatives of traditional metal coronary drug-eluting stents (des), and has a revolutionary influence on the treatment of cardiovascular disease.
