课题将通过研究镁合金支架材料在体外模拟环境中的拉压、疲劳等力学性能的变化规律，揭示支架材料在动物体内的结构完整性、支撑强度衰减规律；研究支架材料在体外/血液环境中的降解行为，阐明其离子释放的动力学特征；研究支架材料对血管内皮细胞和平滑肌细胞粘附、增殖和分化的作用效应，探索其在动物血管内降解产物的代谢转运机理。 本课题的开展将从理论上阐明镁合金支架在体内降解过程与血管组织重构在时间、空间、力学、生物学功效上的适配机制，不仅能为医用镁合金冠脉支架在临床上的应用提供科学依据，也将为可降解医用镁合金材料拓展应用于其他医疗植入领域提供科学参考。

This project will reveal the structural integrity and attenuation law of support strength of magnesium alloy stents in animals by studying the change law of tensile, compression, fatigue and other mechanical properties of magnesium alloy stents in the simulated environment in vitro. We will study the degradation behavior of stent materials in vitro/blood environment and elucidate the kinetic characteristics of ion release, and sumarise the effects of stent materials on the adhesion, proliferation and differentiation of vascular endothelial cells and smooth muscle cells. The metabolic and transport mechanism of stents' degradation products in animal blood vessels was also emplored. The development of this project will theoretically expound the relationship of magnesium alloy stents degradation process in the body and the blood vessels tissue reconstruction in time, space, mechanics, biology effect, which not only can provide medical magnesium alloys in the clinical application but also for application of biodegradable medical magnesium alloy materials in other medical implant field.